MTV made the announcement this afternoon via their social networking sites Twitter, Facebook, Instagram and Vine.
The 36-year-old Kanye will make his seventh onstage appearance at the annual awards when he sings Black Skinhead at the ceremony, which will air live from the Barclays Center in Brooklyn, New York.
Big night: Kanye West has been confirmed to perform at the MTV Video Music Awards on August 25; the rapper is pictured performing in New York in 2010
Lady Gaga is slated to debut her new single at the star-studded event, making this one of her first appearances since having hip surgery in February.
The 27-year-old singer, who will release her new album ARTPOP on November 11, sang the national anthem at New York's Gay Pride in June.
Girl power: Lady Gaga is also set to perform at the annual awards show taking place at Barclays Center in Brooklyn, New York; the singer is likely to deliver a heart-pumping show as she did here in Milan last year
Seven times the charm: This will make Kanye's seventh onstage performance at the MTV Video Awards; he is seen here entertaining the masses at a Los Angeles party in 2011
The operation left her temporarily wheelchair-bound.
The blonde singer recently revealed that her new album will visit the pain of her past and dramatically described the moment she handed the first single over to her record label.
In a post on her new website, LittleMonsters.com, Gaga wrote: 'ARTPOP as they pry the single from my bleeding fingers. its a scary thing to revisit those things underneath, the pain in your past. but all I found was raw passion. I thought I was destroyed inside. i'm just ready to fight. start the music.'
Other performers will be announced at a later date but Justin Timberlake and Macklemore & Ryan Lewis lead the nominations, as they are both up for six awards.